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    {
      "page": "cir-package",
      "title": "Isotonic Regression, Centered Isotonic Regression, and Dose-Response Utilities",
      "topics": [
        "cir-package",
        "cir"
      ]
    },
    {
      "page": "cirPAVA",
      "title": "Centered-isotonic-regression (CIR) point estimation",
      "topics": [
        "cirPAVA"
      ]
    },
    {
      "page": "deltaInverse",
      "title": "Backend utility to calculate inverse (dose-finding) intervals, using local inversion and the Delta method",
      "topics": [
        "deltaInverse"
      ]
    },
    {
      "page": "doseFind",
      "title": "Inverse (dose-finding) point estimate (e.g., estimating a percentile)",
      "topics": [
        "doseFind"
      ]
    },
    {
      "page": "DRshrink",
      "title": "Shrinkage fix to mitigate bias in observed rates, under adaptive dose-finding designs",
      "topics": [
        "DRshrink"
      ]
    },
    {
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      "title": "Constructor functions and class-checking functions for DRtrace and doseResponse classes",
      "topics": [
        "doseResponse",
        "DRtrace",
        "is.doseResponse",
        "is.DRtrace"
      ]
    },
    {
      "page": "isotInterval",
      "title": "Backend utility to calculate analytical CIR/IR interval estimates, given the point estimates",
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        "isotInterval"
      ]
    },
    {
      "page": "morrisCI",
      "title": "Analytical ordered-binary-Y confidence intervals, using the Morris (1988) algorithm",
      "topics": [
        "morrisCI"
      ]
    },
    {
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      "title": "\"Old School\" isotonic-regression point estimates, with flexible dose-response input",
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      ]
    },
    {
      "page": "plot.DRtrace",
      "title": "Plotting Methods for DRtrace, doseResponse Objects",
      "topics": [
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        "plot.DRtrace"
      ]
    },
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      "page": "quickInverse",
      "title": "Convenient point and Interval Inverse Estimation (\"Dose-Finding\"), using CIR or IR",
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        "quickInverse"
      ]
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        "quickIsotone"
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      ]
    },
    {
      "page": "wilsonCI",
      "title": "Standard unordered-Binomial confidence interval utilities.",
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        "jeffCI",
        "wilsonCI"
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      "engine": "knitr::rmarkdown",
      "headings": [
        "Overview",
        "The Study in our Example",
        "Experimental Trajectories",
        "Dose-Response Plot and ED$_{50}$ Estimates",
        "Other Notes",
        "Comparing the Two Arms",
        "Visualizing CIR on the Dose-Response Plane",
        "Notes",
        "References"
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      "created": "2023-03-04 22:05:59",
      "modified": "2026-02-15 03:53:21",
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