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  "Title": "Centered Isotonic Regression and Dose-Response Utilities",
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  "Date": "2026-02-18",
  "Description": "Isotonic regression (IR) and its improvement: centered\nisotonic regression (CIR). CIR is recommended in particular\nwith small samples. Also, interval estimates for both, and\nadditional utilities such as plotting dose-response data. For\ndev version and change history, see GitHub assaforon/cir.",
  "License": "GPL-2",
  "Authors@R": "person('Assaf P.','Oron', role=c('cre','aut'), email='assaf.oron@gmail.com')",
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    },
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    },
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    },
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    "deltaInverse",
    "doseFind",
    "doseResponse",
    "DRshrink",
    "DRtrace",
    "is.doseResponse",
    "is.DRtrace",
    "isotInterval",
    "jeffCI",
    "morrisCI",
    "oldPAVA",
    "quickInverse",
    "quickIsotone",
    "slope",
    "wilsonCI"
  ],
  "_help": [
    {
      "page": "cir-package",
      "title": "Isotonic Regression, Centered Isotonic Regression, and Dose-Response Utilities",
      "topics": [
        "cir-package",
        "cir"
      ]
    },
    {
      "page": "cirPAVA",
      "title": "Centered-isotonic-regression (CIR) point estimation",
      "topics": [
        "cirPAVA"
      ]
    },
    {
      "page": "deltaInverse",
      "title": "Backend utility to calculate inverse (dose-finding) intervals, using local inversion and the Delta method",
      "topics": [
        "deltaInverse"
      ]
    },
    {
      "page": "doseFind",
      "title": "Inverse (dose-finding) point estimate (e.g., estimating a percentile)",
      "topics": [
        "doseFind"
      ]
    },
    {
      "page": "DRshrink",
      "title": "Shrinkage fix to mitigate bias in observed rates, under adaptive dose-finding designs",
      "topics": [
        "DRshrink"
      ]
    },
    {
      "page": "DRtrace",
      "title": "Constructor functions and class-checking functions for DRtrace and doseResponse classes",
      "topics": [
        "doseResponse",
        "DRtrace",
        "is.doseResponse",
        "is.DRtrace"
      ]
    },
    {
      "page": "isotInterval",
      "title": "Backend utility to calculate analytical CIR/IR interval estimates, given the point estimates",
      "topics": [
        "isotInterval"
      ]
    },
    {
      "page": "morrisCI",
      "title": "Analytical ordered-binary-Y confidence intervals, using the Morris (1988) algorithm",
      "topics": [
        "morrisCI"
      ]
    },
    {
      "page": "oldPAVA",
      "title": "\"Old School\" isotonic-regression point estimates, with flexible dose-response input",
      "topics": [
        "oldPAVA"
      ]
    },
    {
      "page": "plot.DRtrace",
      "title": "Plotting Methods for DRtrace, doseResponse Objects",
      "topics": [
        "plot.doseResponse",
        "plot.DRtrace"
      ]
    },
    {
      "page": "quickInverse",
      "title": "Convenient point and Interval Inverse Estimation (\"Dose-Finding\"), using CIR or IR",
      "topics": [
        "quickInverse"
      ]
    },
    {
      "page": "quickIsotone",
      "title": "Convenient Forward point and interval estimation via CIR or IR",
      "topics": [
        "quickIsotone"
      ]
    },
    {
      "page": "slope",
      "title": "Piecewise-linear local slopes given a (non-strictly) monotone x-y sequence",
      "topics": [
        "slope"
      ]
    },
    {
      "page": "wilsonCI",
      "title": "Standard unordered-Binomial confidence interval utilities.",
      "topics": [
        "agcouCI",
        "jeffCI",
        "wilsonCI"
      ]
    }
  ],
  "_rundeps": [],
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      "source": "BenHamou03.rmd",
      "filename": "BenHamou03.html",
      "title": "Vignette for the cir Package",
      "author": "Assaf Oron",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Overview",
        "The Study in our Example",
        "Experimental Trajectories",
        "Dose-Response Plot and ED$_{50}$ Estimates",
        "Other Notes",
        "Comparing the Two Arms",
        "Visualizing CIR on the Dose-Response Plane",
        "Notes",
        "References"
      ],
      "created": "2023-03-04 22:05:59",
      "modified": "2026-02-15 03:53:21",
      "commits": 12
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