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  "Title": "Utilities and Design Aids for Up-and-Down Dose-Finding Studies",
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  "Date": "2025-12-30",
  "Description": "Up-and-Down (UD) is the most popular design approach for\ndose-finding, but it has been severely under-served by the\nstatistical and computing communities. This is the first\npackage that comprehensively addresses UD's needs. Development\nversion available on Github: assaforon/upndown. Recent applied\nUD tutorial: Oron et al., 2022\n<doi:10.1097/ALN.0000000000004282>. Recent methodological\noverview: Oron and Flournoy, 2024 <doi:10.51387/24-NEJSDS74>.",
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  "Authors@R": "person('Assaf P.','Oron', role=c('cre','aut'), email='assaf.oron@gmail.com')",
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  "Date/Publication": "2025-10-26 01:21:03 UTC",
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      "title": "Transition Probability Matrices for Up-and-Down Designs",
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        "classicmat",
        "gudmat",
        "kmatFull",
        "kmatMarg"
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        "dfboot"
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      "title": "Generalized Dose-Finding Ensemble Simulator",
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      ]
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      "page": "dixonmood",
      "title": "Original Dixon and Mood (1948) point estimate",
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      ]
    },
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      "page": "drplot",
      "title": "Visualizing the dose-response summary of an up-and-down experiment",
      "topics": [
        "drplot"
      ]
    },
    {
      "page": "dynamean",
      "title": "Up-and-Down target-dose averaging estimate, with dynamic cutoff-point",
      "topics": [
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    },
    {
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      "title": "Up-and-Down Target Calculation and Design Guidance",
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        "g2targ",
        "gtargOptions",
        "k2targ",
        "ktargOptions"
      ]
    },
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        "groupUD",
        "krow"
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        "currentvec",
        "pivec"
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      "page": "udplot",
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      "topics": [
        "udplot"
      ]
    },
    {
      "page": "validUDinput",
      "title": "Data Validation Utilities for 'upndown'",
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        "checkDose",
        "checkNatural",
        "checkResponse",
        "checkTarget",
        "validUDinput"
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      "title": "upndown Package Vignette 1: Up-and-Down Basics",
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        "What Makes a Design \"Up-and-Down\"?",
        "Experimental Examples",
        "Material Strength Testing",
        "Important Note: Observation Bias and Empirical Correction",
        "$ED_{90}$ of Vasopressor during Caesarean Section"
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