Package: upndown 0.1.0

upndown: Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Up-and-Down is the most popular design approach for dose-finding, but has been severely under-served by the statistical computing community. This is the first package to address Up-and-Down's needs. For a recent methodological tutorial on Up-and-Down, see Oron et al. (2022) <doi:10.1097/ALN.0000000000004282>.

Authors:Assaf P. Oron [cre, aut]

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upndown.pdf |upndown.html✨
upndown/json (API)

# Install 'upndown' in R:

install.packages('upndown', repos = c('https://assaforon.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/assaforon/upndown/issues

On CRAN:

4.10 score 14 scripts 147 downloads 31 exports 7 dependencies

Last updated 8 months agofrom:dee7a2360a. Checks:ERROR: 7. Indexed: yes.

Target	Result	Date
Doc / Vignettes	FAIL	Nov 22 2024
R-4.5-win	ERROR	Nov 22 2024
R-4.5-linux	ERROR	Nov 22 2024
R-4.4-win	ERROR	Nov 22 2024
R-4.4-mac	ERROR	Nov 22 2024
R-4.3-win	ERROR	Nov 22 2024
R-4.3-mac	ERROR	Nov 22 2024

Exports:bcd bcdmat bcoin checkCDF checkDose checkNatural checkResponse checkTarget classicmat cumulvec currentvec dfboot dfsim dixonmood drplot dynamean g2targ groupUD gtargOptions gudmat k2targ kmatFull kmatMarg krow ktargOptions pivec reversals reversmean udest udplot validUDinput

Dependencies:cir expm lattice Matrix numbers plyr Rcpp

Vignettes and/or manual for this package failed to build, some documents may be unavailable. Please inspect thebuild logs for more information.

upndown Package Vignette 1: Up-and-Down Basics

Assaf Oron

Rendered fromupndown_basics.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2023-06-07
Started: 2023-01-02

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Transition Probability Matrices for Up-and-Down Designs	bcdmat classicmat gudmat kmatFull kmatMarg
Generic percentile dose-response / dose-finding bootstrap routine	dfboot
Generalized Dose-Finding Ensemble Simulator	dfsim
Original Dixon and Mood (1948) point estimate	dixonmood
Visualizing the dose-response summary of an up-and-down experiment	drplot
Up-and-Down target-dose averaging estimate, with dynamic cutoff-point	dynamean
Up-and-Down Target Calculation and Design Guidance	bcoin g2targ gtargOptions k2targ ktargOptions
Up-and-Down Design Rules for use in Dose-Finding Simulator	krow
Key Probability Vectors of Up-and-Down Designs	cumulvec currentvec pivec
Reversal-anchored averaging estimators for Up-and-Down	reversals reversmean
Centered-Isotonic-Regression (CIR) Estimate for the Up-and-Down Target Dose	udest
Visualizing the time series of an up-and-down experiment	udplot
Data Validation Utilities for 'upndown'	checkCDF checkDose checkNatural checkResponse checkTarget validUDinput