Package: upndown 0.3.0
upndown: Utilities and Design Aids for Up-and-Down Dose-Finding Studies
Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package to address UD's needs. Recent applied UD tutorial: Oron et al., 2022 <doi:10.1097/ALN.0000000000004282>. Recent methodological overview: Oron and Flournoy, 2024 <doi:10.51387/24-NEJSDS74>.
Authors:
upndown_0.3.0.tar.gz
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upndown_0.3.0.tgz(r-4.5-any)upndown_0.3.0.tgz(r-4.4-any)upndown_0.3.0.tgz(r-4.3-any)
upndown_0.3.0.tar.gz(r-4.5-noble)upndown_0.3.0.tar.gz(r-4.4-noble)
upndown_0.3.0.tgz(r-4.4-emscripten)upndown_0.3.0.tgz(r-4.3-emscripten)
upndown.pdf |upndown.html✨
upndown/json (API)
| # Install 'upndown' in R: |
| install.packages('upndown', repos = c('https://assaforon.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/assaforon/upndown/issues
Last updated 17 days agofrom:422c542bb2. Checks:9 OK. Indexed: yes.
| Target | Result | Latest binary |
|---|---|---|
| Doc / Vignettes | OK | Mar 09 2025 |
| R-4.5-win | OK | Mar 09 2025 |
| R-4.5-mac | OK | Mar 09 2025 |
| R-4.5-linux | OK | Mar 09 2025 |
| R-4.4-win | OK | Mar 09 2025 |
| R-4.4-mac | OK | Mar 09 2025 |
| R-4.4-linux | OK | Mar 09 2025 |
| R-4.3-win | OK | Mar 09 2025 |
| R-4.3-mac | OK | Mar 09 2025 |
Exports:bcdbcdmatbcoincheckCDFcheckDosecheckNaturalcheckResponsecheckTargetclassicmatcumulveccurrentvecdfbootdfsimdixonmooddrplotdynameang2targgroupUDgtargOptionsgudmatk2targkmatFullkmatMargkrowktargOptionspivecreversalsreversmeanudestudplotvalidUDinput
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Transition Probability Matrices for Up-and-Down Designs | bcdmat classicmat gudmat kmatFull kmatMarg |
| Generic percentile dose-response / dose-finding bootstrap routine | dfboot |
| Generalized Dose-Finding Ensemble Simulator | dfsim |
| Original Dixon and Mood (1948) point estimate | dixonmood |
| Visualizing the dose-response summary of an up-and-down experiment | drplot |
| Up-and-Down target-dose averaging estimate, with dynamic cutoff-point | dynamean |
| Up-and-Down Target Calculation and Design Guidance | bcoin g2targ gtargOptions k2targ ktargOptions |
| Up-and-Down Design Rules for use in Dose-Finding Simulator | bcd groupUD krow |
| Key Probability Vectors of Up-and-Down Designs | cumulvec currentvec pivec |
| Reversal-anchored averaging estimators for Up-and-Down | reversals reversmean |
| Centered-Isotonic-Regression (CIR) Estimate for the Up-and-Down Target Dose | udest |
| Visualizing the time series of an up-and-down experiment | udplot |
| Data Validation Utilities for 'upndown' | checkCDF checkDose checkNatural checkResponse checkTarget validUDinput |
