Package: upndown 0.4.0

upndown: Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Development version available on Github: assaforon/upndown. Recent applied UD tutorial: Oron et al., 2022 <doi:10.1097/ALN.0000000000004282>. Recent methodological overview: Oron and Flournoy, 2024 <doi:10.51387/24-NEJSDS74>.

Authors:Assaf P. Oron [cre, aut]

upndown_0.4.0.tar.gz
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upndown_0.4.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
upndown/json (API)

# Install 'upndown' in R:

install.packages('upndown', repos = c('https://assaforon.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/assaforon/upndown/issues

On CRAN:

3.30 score 1 stars 20 scripts 210 downloads 32 exports 7 dependencies

Last updated from:97293500f3. Checks:7 WARNING, 2 OK. Indexed: yes.

Target	Result	Time
linux-devel	WARNING	107
source / vignettes	OK	152
linux-release	WARNING	108
macos-release	WARNING	100
macos-oldrel	WARNING	103
windows-devel	WARNING	54
windows-release	WARNING	52
windows-oldrel	WARNING	69
wasm-release	OK	82

Exports:armDiffCI bcd bcdmat bcoin checkCDF checkDose checkNatural checkResponse checkTarget classicmat cumulvec currentvec dfboot dfsim dixonmood drplot dynamean g2targ groupUD gtargOptions gudmat k2targ kmatFull kmatMarg krow ktargOptions pivec reversals reversmean udest udplot validUDinput

Dependencies:cir expm lattice MASS Matrix plyr Rcpp

upndown Package Vignette 1: Up-and-Down Basics

Background | What Makes a Design "Up-and-Down"? | Experimental Examples | Material Strength Testing | Important Note: Observation Bias and Empirical Correction | $ED_{90}$ of Vasopressor during Caesarean Section

Rendered fromupndown_basics.Rmdusingknitr::rmarkdown

Last update: 2025-06-16
Started: 2023-01-02

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Transition Probability Matrices for Up-and-Down Designs	bcdmat classicmat gudmat kmatFull kmatMarg
Generic percentile dose-response / dose-finding bootstrap routine	dfboot
Generalized Dose-Finding Ensemble Simulator	dfsim
Original Dixon and Mood (1948) point estimate	dixonmood
Visualizing the dose-response summary of an up-and-down experiment	drplot
Up-and-Down target-dose averaging estimate, with dynamic cutoff-point	dynamean
Up-and-Down Target Calculation and Design Guidance	bcoin g2targ gtargOptions k2targ ktargOptions
Up-and-Down Design Rules for use in Dose-Finding Simulator	bcd groupUD krow
Key Probability Vectors of Up-and-Down Designs	cumulvec currentvec pivec
Reversal-anchored averaging estimators for Up-and-Down	reversals reversmean
Centered-Isotonic-Regression (CIR) Estimate for the Up-and-Down Target Dose	udest
Visualizing the time series of an up-and-down experiment	udplot
Data Validation Utilities for 'upndown'	checkCDF checkDose checkNatural checkResponse checkTarget validUDinput